Which factor is a risk for systemic adverse effects from topical corticosteroids?

Which factor is a risk for systemic adverse effects from topical corticosteroids?

• A. Malnourishment
• B. Regular exercise
• C. Adequate hydration
• D. Sun exposure

Answer: (D)

Systemic adverse effects from topical corticosteroids happen when the medication is absorbed into the bloodstream. Sun exposure can increase this risk because ultraviolet light damages the skin barrier, making the skin more permeable and capable of letting more steroid pass into the circulation. UV-induced changes can also increase local blood flow, further facilitating absorption. The other options don’t directly raise systemic absorption in typical use: malnourishment isn’t a direct driver of skin absorption, and regular exercise or adequate hydration don’t increase how much topical steroid enters the bloodstream.

Systemic adverse effects from topical corticosteroids happen when the medication is absorbed into the bloodstream. Sun exposure can increase this risk because ultraviolet light damages the skin barrier, making the skin more permeable and capable of letting more steroid pass into the circulation. UV-induced changes can also increase local blood flow, further facilitating absorption. The other options don’t directly raise systemic absorption in typical use: malnourishment isn’t a direct driver of skin absorption, and regular exercise or adequate hydration don’t increase how much topical steroid enters the bloodstream.